Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cellular Oncology"
DOI: 10.1007/s13402-022-00659-8
Abstract: Purpose Hepatocellular carcinoma (HCC) is one of the most common cancers in the world with a high mortality rate. Receptor tyrosine kinases play important roles in the occurrence and development of various cancers. Discoid protein… read more here.
Keywords: expression; hcc; slc1a5; receptor ... See more keywords
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.01.012
Abstract: Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be activated from its quiescent contractile phenotype to a… read more here.
Keywords: vascular smooth; phenotype; dnmt1; ddr1 ... See more keywords
Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer1
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.02.003
Abstract: Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated… read more here.
Keywords: ddr1; gastric cancer; metastasis; ddr1 silenced ... See more keywords
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04057-2
Abstract: Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)1. The extracellular matrix (ECM) contributes to immune exclusion2. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4.… read more here.
Keywords: exclusion; immune exclusion; fibre alignment; collagen fibre ... See more keywords
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51066-3
Abstract: Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth… read more here.
Keywords: small cell; tmprss4 ddr1; ddr1; non small ... See more keywords
Effects of DDR1 on migration and adhesion of periodontal ligament cells and the underlying mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.12986
Abstract: BACKGROUND AND OBJECTIVE As one of the widely expressed cell surface receptors binding to collagen, the most abundant component of the extracellular matrix (ECM), knowledge of the expression, functions, and mechanisms underlying the role of… read more here.
Keywords: ddr1; hpdlcs; migration adhesion; mek ... See more keywords
Abstract 5010: Inhibition of discoidin domain receptor 1 (DDR1) as a new therapeutic strategy for osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5010
Abstract: Osteosarcoma is the most common type of bone cancer. Current management for osteosarcoma includes neoadjuvant chemotherapy and surgery. Unfortunately, some patients eventually develop recurrent or metastatic diseases and treatment options are extremely limited. Discoidin domain… read more here.
Keywords: inhibition; osteosarcoma; discoidin domain; ddr1 ... See more keywords
Liquid-Liquid Phase Separation of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.322113
Abstract: Background: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cues. Activation of YAP in vascular smooth muscle cells conveys the extracellular matrix stiffness-induced changes in vascular smooth muscle cells phenotype… read more here.
Keywords: hippo pathway; liquid phase; ddr1; phase separation ... See more keywords
DDR1 Deficiency in Mice: A Spontaneous Model of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension?
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0312ed
Abstract: Bronchopulmonary dysplasia (BPD) is the most commonmorbidity associated with preterm birth, affecting up to 50–60% of babies born with birth weights less than 1,000 grams when the lungs are at the saccular stage of development… read more here.
Keywords: cell; hypertension; ddr1; pathology ... See more keywords
Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Dental Research"
DOI: 10.1177/0022034519881136
Abstract: The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues,… read more here.
Keywords: ddr1; histology; bone; ddr1 versus ... See more keywords
Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-017-0333-4
Abstract: BackgroundDiscoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers the progression of various cancers. Aberrant expression of DDR1 was detected in several human cancers including ovarian cancer, which… read more here.
Keywords: 199a promoter; mir 199a; expression; ovarian cancer ... See more keywords