Evaluation of Discoidin domain receptor 1 (DDR1) in junctional epithelial permeability and wound healing.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of periodontology"
DOI: 10.1002/jper.70031
Abstract: BACKGROUND Epithelium is the periodontal first line of defense against microbes. Discoidin domain receptor 1 (DDR1) is a collagen receptor expressed in epithelium. Ddr1 knockout (Ddr1-/-) mice develop periodontitis-like defects, including junctional epithelium (JE) downgrowth,… read more here.
Keywords: receptor; permeability; ddr1 mice; ddr1 ... See more keywords
Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cellular Oncology"
DOI: 10.1007/s13402-022-00659-8
Abstract: Purpose Hepatocellular carcinoma (HCC) is one of the most common cancers in the world with a high mortality rate. Receptor tyrosine kinases play important roles in the occurrence and development of various cancers. Discoid protein… read more here.
Keywords: expression; hcc; slc1a5; receptor ... See more keywords
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.01.012
Abstract: Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be activated from its quiescent contractile phenotype to a… read more here.
Keywords: vascular smooth; phenotype; dnmt1; ddr1 ... See more keywords
Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer1
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.02.003
Abstract: Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated… read more here.
Keywords: ddr1; gastric cancer; metastasis; ddr1 silenced ... See more keywords
Synthesis and Preclinical Evaluation of DDR1-Targeted Radiotracers for Colorectal Cancer Diagnosis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01224
Abstract: Colorectal cancer (CRC) is one of the most common tumors, and discoidin domain receptor 1 (DDR1) expression is significantly higher in CRC. In this study, we designed and synthesized eight novel 68Ga-labeled DDR1-targeted radiotracers. The… read more here.
Keywords: colorectal cancer; diagnosis; ddr1 targeted; ddr1 ... See more keywords
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04057-2
Abstract: Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)1. The extracellular matrix (ECM) contributes to immune exclusion2. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4.… read more here.
Keywords: exclusion; immune exclusion; fibre alignment; collagen fibre ... See more keywords
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51066-3
Abstract: Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth… read more here.
Keywords: small cell; tmprss4 ddr1; ddr1; non small ... See more keywords
DDR1 Targeting HOXA6 Facilitates Bladder Cancer Progression via Inhibiting Ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70410
Abstract: Ferroptosis is an important factor affecting the progression of bladder cancer (BC). Previous studies have confirmed that discoidin domain receptor 1 (DDR1) promotes BC progression. However, the regulatory mechanisms of BC ferroptosis are largely unknown.… read more here.
Keywords: progression; targeting hoxa6; ddr1; ferroptosis ... See more keywords
Effects of DDR1 on migration and adhesion of periodontal ligament cells and the underlying mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.12986
Abstract: BACKGROUND AND OBJECTIVE As one of the widely expressed cell surface receptors binding to collagen, the most abundant component of the extracellular matrix (ECM), knowledge of the expression, functions, and mechanisms underlying the role of… read more here.
Keywords: ddr1; hpdlcs; migration adhesion; mek ... See more keywords
Abstract 5010: Inhibition of discoidin domain receptor 1 (DDR1) as a new therapeutic strategy for osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5010
Abstract: Osteosarcoma is the most common type of bone cancer. Current management for osteosarcoma includes neoadjuvant chemotherapy and surgery. Unfortunately, some patients eventually develop recurrent or metastatic diseases and treatment options are extremely limited. Discoidin domain… read more here.
Keywords: inhibition; osteosarcoma; discoidin domain; ddr1 ... See more keywords
Abstract 304: The role of DDR1 mediated E-cadherin stability in collective colon cancer cell migration
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-304
Abstract: In cancer metastasis, the mechanism of single cell migration and collective cell migration are investigated. The dynamics of E-cadherin is critical in collective cell migration as the important mechanism of metastasis. DDR1 (Discoidin Domain Receptor… read more here.
Keywords: cancer; cell migration; ddr1; cell ... See more keywords