Special issue “The advance of solid tumor research in China”: Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34227
Abstract: Tumor metastasis is one of the main reasons for the high mortality rate associated with colorectal cancer (CRC). However, its underlying mechanisms have not been fully understood. Here, we reported that the expression of discoidin… read more here.
Keywords: metastasis; discoidin domain; crc; colorectal cancer ... See more keywords
DDR2, a discoidin domain receptor, is a marker of periosteal osteoblast and osteoblast progenitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01108-y
Abstract: The periosteum has a bilayered structure that surrounds cortical bone. The outer layer is rich in connective tissue and fibroblasts, while the inner layer in contact with the cortical surface of the bone predominantly consists… read more here.
Keywords: osteoblast progenitors; bone; ddr2; periosteum ... See more keywords
Abstract B16: Prognostic evaluation of components associated with epithelium-mesenchymal transition in women with serous carcinoma of high ovary grade
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-b16
Abstract: Introduction: High-grade serous ovarian carcinoma (HGSOC) is a heterogeneous disease with high mortality. Initially most women respond to platinum chemotherapy, but rapidly many become resistant to the drug and progress to relapse and death. Better… read more here.
Keywords: mesenchymal transition; platinum; grade; ddr2 ... See more keywords
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00388-y
Abstract: Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor… read more here.
Keywords: wound healing; c1q; ddr2; domain receptor ... See more keywords
Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties.
Sign Up to like & getrecommendations! Published in 2023 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4251118
Abstract: We report the synthesis, molecular docking and anticancer properties of the novel compound (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one (PP562). PP562 was screened against sixteen human cancer cell lines and exhibited excellent antiproliferative activity with IC50 values ranging from 0.016… read more here.
Keywords: molecular docking; cell; synthesis molecular; anticancer ... See more keywords