DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103086
Abstract: Summary Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in oral squamous cell carcinoma (OSCC) cells. Ribo-seq analysis confirmed amphiregulin (AREG) as a translational target of… read more here.
Keywords: ddx3 modulates; endoplasmic reticulum; ddx3; reticulum associated ... See more keywords
Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab667
Abstract: Abstract DDX3 is a multifaceted RNA helicase of the DEAD-box family that plays central roles in all aspects of RNA metabolism including translation initiation. Here, we provide evidence that the Leishmania DDX3 ortholog functions in… read more here.
Keywords: ddx3; rna helicase; elongation; translating ribosomes ... See more keywords
The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/8596135
Abstract: DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. In… read more here.
Keywords: alkbh5; ddx3; rna; dead box ... See more keywords
Role of DDX3 in the pathogenesis of inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.23323
Abstract: When crypt stem cells of the gastrointestinal tract become injured, the result is increased synthesis of pro-inflammatory cytokines and matrix metalloproteinases by their progeny – the colonic epithelium. Chronic inflammation of the gastrointestinal tract is… read more here.
Keywords: inflammatory bowel; ddx3; inflammatory; bowel disease ... See more keywords
Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer
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DOI: 10.2147/ott.s140639
Abstract: Purpose DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has… read more here.
Keywords: ddx3; nuclear ddx3; colorectal breast; breast cancer ... See more keywords
DDX3 Upregulates Hydrogen Peroxide-Induced Melanogenesis in Sk-Mel-2 Human Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207010
Abstract: DDX3 is a DEAD-box RNA helicase with diverse biological functions through multicellular pathways. The objective of this study was to investigate the role of DDX3 in regulating melanogenesis by the exploring signaling pathways involved. Various… read more here.
Keywords: hydrogen peroxide; ddx3; melanoma cells; mel human ... See more keywords