The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Journal"
DOI: 10.1042/bcj20170354
Abstract: DDX3X, a helicase, can interact directly with mRNA and translation initiation factors, regulating the selective translation of mRNAs that contain a structured 5′ untranslated region. This activity modulates the expression of mRNAs controlling cell cycle… read more here.
Keywords: protein; leading edge; ddx3x; edge migrating ... See more keywords
DDX3: a relevant therapeutic target for lymphoma?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2166830
Abstract: DDX3X is an RNA-helicase that unwinds RNA complexes and regulates mRNA translation [1]. The DDX3X protein is highly conserved between mice and humans (98%) and contains a helicase and an ATP-binding domain. The DDX3X gene… read more here.
Keywords: lymphoma; ddx3y; cell lymphoma; ddx3x ... See more keywords
DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replication via Stabilization of the Phosphoprotein
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DOI: 10.1128/jvi.00035-23
Abstract: Growing evidence has suggested that DDX3X plays important roles in virus replication. In one respect, DDX3X inhibits the replication of viruses, including hepatitis B virus, influenza A virus, Newcastle disease virus, duck Tembusu virus, and… read more here.
Keywords: phosphoprotein; shvv; replication; ddx3x ... See more keywords
The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis.
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DOI: 10.1158/0008-5472.can-21-2454
Abstract: The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active DDX3X alleles and males carry a DDX3Y homolog on the… read more here.
Keywords: lymphomagenesis; driven lymphomagenesis; helicase ddx3x; ddx3x ... See more keywords
Abstract 3919: SHP2-DDX3X complexes contribute to translational control of CD274 mRNA in KRAS-active non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3919
Abstract: Background: Immune checkpoint inhibitors (ICIs) have shifted the landscape in management for non-small cell lung cancer (NSCLC) and improve treatment outcomes. However, the 5-year overall survival rate of 23.2% for treatment-naïve patients with late-stage NSCLC… read more here.
Keywords: cd274 mrna; cell; shp2; expression ... See more keywords
DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653883
Abstract: Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivotal for optimal control of pathogens and avoidance of immunopathology. The human Nod-like receptor (NLR) NLRP11 has been shown to regulate type… read more here.
Keywords: inflammasome activation; type ifn; ddx3x; activation ... See more keywords
Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X
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DOI: 10.3390/ijms21176449
Abstract: Casein Kinase 1 epsilon (CK1ε) is a member of the serine (Ser)/threonine (Thr) CK1 family, known to have crucial roles in several biological scenarios and, ever more frequently, in pathological contexts, such as cancer. Recently,… read more here.
Keywords: ck1; functional interplay; novel insights; casein ... See more keywords