DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05195-8
Abstract: Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism was still unclear. DDX3X, a member of the DEAD-box helicase family, has a major effect on immune… read more here.
Keywords: neuronal pyroptosis; ddx3x; via nlrp3; nlrp3 inflammasome ... See more keywords
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Journal"
DOI: 10.1042/bcj20170354
Abstract: DDX3X, a helicase, can interact directly with mRNA and translation initiation factors, regulating the selective translation of mRNAs that contain a structured 5′ untranslated region. This activity modulates the expression of mRNAs controlling cell cycle… read more here.
Keywords: protein; leading edge; ddx3x; edge migrating ... See more keywords
DDX3: a relevant therapeutic target for lymphoma?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2166830
Abstract: DDX3X is an RNA-helicase that unwinds RNA complexes and regulates mRNA translation [1]. The DDX3X protein is highly conserved between mice and humans (98%) and contains a helicase and an ATP-binding domain. The DDX3X gene… read more here.
Keywords: lymphoma; ddx3y; cell lymphoma; ddx3x ... See more keywords
Pathogenic mutations disrupt stress granules assembly in patients with DDX3X neurodevelopmental disorder.
Sign Up to like & getrecommendations! Published in 2025 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaf083
Abstract: DDX3X neurodevelopmental disorder (DDX3X-NDD) represents a recently identified genetic syndrome characterized by intellectual disability (ID) and developmental delays, primarily caused by pathogenic variants in the DDX3X gene. The physiological ramifications of these mutations remain largely… read more here.
Keywords: ddx3x; neurodevelopmental disorder; stress; stress granules ... See more keywords
DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replication via Stabilization of the Phosphoprotein
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00035-23
Abstract: Growing evidence has suggested that DDX3X plays important roles in virus replication. In one respect, DDX3X inhibits the replication of viruses, including hepatitis B virus, influenza A virus, Newcastle disease virus, duck Tembusu virus, and… read more here.
Keywords: phosphoprotein; shvv; replication; ddx3x ... See more keywords
The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2454
Abstract: The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active DDX3X alleles and males carry a DDX3Y homolog on the… read more here.
Keywords: lymphomagenesis; driven lymphomagenesis; helicase ddx3x; ddx3x ... See more keywords
Abstract 3919: SHP2-DDX3X complexes contribute to translational control of CD274 mRNA in KRAS-active non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3919
Abstract: Background: Immune checkpoint inhibitors (ICIs) have shifted the landscape in management for non-small cell lung cancer (NSCLC) and improve treatment outcomes. However, the 5-year overall survival rate of 23.2% for treatment-naïve patients with late-stage NSCLC… read more here.
Keywords: cd274 mrna; cell; shp2; expression ... See more keywords
DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653883
Abstract: Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivotal for optimal control of pathogens and avoidance of immunopathology. The human Nod-like receptor (NLR) NLRP11 has been shown to regulate type… read more here.
Keywords: inflammasome activation; type ifn; ddx3x; activation ... See more keywords
Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21176449
Abstract: Casein Kinase 1 epsilon (CK1ε) is a member of the serine (Ser)/threonine (Thr) CK1 family, known to have crucial roles in several biological scenarios and, ever more frequently, in pathological contexts, such as cancer. Recently,… read more here.
Keywords: ck1; functional interplay; novel insights; casein ... See more keywords