Clinical and Pathologic Spectrum of DDX41-Mutated Hematolymphoid Neoplasms.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqab027
Abstract: OBJECTIVES This study seeks to further characterize the clinicopathologic spectrum of DDX41-mutated hematolymphoid malignancies. METHODS We identified DDX41 mutations from a cohort of known or suspected hematologic disorders and reviewed the corresponding clinical, genetic, phenotypic,… read more here.
Keywords: mutated hematolymphoid; ddx41 mutated; ddx41; case ... See more keywords
High-Throughput Screening to Identify Inhibitors of DEAD Box Helicase DDX41
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DOI: 10.1177/2472555217705952
Abstract: The human DEAD (Asp–Glu–Ala–Asp) box protein DDX41, a member of the DEXDc helicase family, has nucleic acid–dependent ATPase and RNA and DNA translocase and unwinding activities. DDX41 is affected by somatic mutations in sporadic cases… read more here.
Keywords: r525h; ddx41; high throughput; helicase ... See more keywords
Excessive R-Loops Trigger an Inflammatory Cascade Leading to Aberrant Hematopoietic Stem and Progenitor Cell Expansion
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DOI: 10.1182/blood-2019-124888
Abstract: Mutations in DEAD-box Helicase 41 (DDX41) are observed in patients with myelodysplastic syndromes (MDS) with inferior overall survival, implicating this factor in disease pathogenesis. DDX41 is an understudied factor with links to inflammation and RNA… read more here.
Keywords: expansion; ddx41; gfp; stem progenitor ... See more keywords
Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasms.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2023.282867
Abstract: The diagnosis of germline predisposition to myeloid neoplasms (MN) secondary to DDX41 variants is currently hindered by the long latency period, variable family histories and the frequent occurrence of DDX41 variants of uncertain significance (VUS).… read more here.
Keywords: ddx41; ddx41 variants; myeloid neoplasms; germline ddx41 ... See more keywords
Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.992340
Abstract: In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), patient selection and therapeutic strategies are increasingly based on tumor-specific genetic mutations. Among these, mutations in DDX41, which encodes a DEAD-box type RNA… read more here.
Keywords: ddx41; rna helicase; leukemogenesis; rna ... See more keywords
Current Understanding of DDX41 Mutations in Myeloid Neoplasms
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DOI: 10.3390/cancers15020344
Abstract: Simple Summary The DEAD-box RNA helicase 41, DDX41, is one of the most frequently identified mutations in myeloid neoplasms with germline predispositions, which represents 2% of the entire MDS/AML population. DDX41 is located at 5q35.3,… read more here.
Keywords: ddx41; current understanding; ddx41 mutations; mutations myeloid ... See more keywords
The Interaction of Mandarin Fish DDX41 with STING Evokes type I Interferon Responses Inhibiting Ranavirus Replication
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DOI: 10.3390/v15010058
Abstract: DDX41 is an intracellular DNA sensor that evokes type I interferon (IFN-I) production via the adaptor stimulator of interferon gene (STING), triggering innate immune responses against viral infection. However, the regulatory mechanism of the DDX41-STING… read more here.
Keywords: ddx41; ranavirus; scddx41; fish ddx41 ... See more keywords