RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32651
Abstract: Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH.… read more here.
Keywords: ddx5; mtorc1; dead box; nonalcoholic steatohepatitis ... See more keywords
Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23477
Abstract: Aberrant alternative splicing (AS) profoundly affects tumorigenesis and cancer progression. Serine/arginine‐rich splicing factor 3 (SRSF3) regulates the AS of precursor mRNAs and acts as a proto‐oncogene in many tumors, but its function and potential mechanisms… read more here.
Keywords: cervical cancer; ddx5; srsf3; factor srsf3 ... See more keywords
RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.002
Abstract: RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA… read more here.
Keywords: ddx5 inhibits; inhibits reprogramming; ddx5; rybp ... See more keywords
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112148
Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Unfortunately, chemo-resistance is a huge obstacle in the treatment of OS. However, the underlying molecular mechanisms of OS chemo-resistance still remain… read more here.
Keywords: degradation; cpt; ddx5; resistance ... See more keywords
DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42876
Abstract: DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5) is an ATP-dependent RNA helicase that is overexpressed in various malignancies. Increasing evidence suggests that DDX5 participates in carcinogenesis and cancer progression via promoting cell proliferation and metastasis. However,… read more here.
Keywords: cancer; cell proliferation; ddx5; gastric cancer ... See more keywords
Knockdown of KRAB domain-associated protein 1 suppresses the proliferation, migration and invasion of thyroid cancer cells by regulating P68/DEAD box protein 5
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2067289
Abstract: ABSTRACT KRAB domain-associated protein 1 (KAP-1) has been reported to be an oncogene in diverse tumors. KAP-1 was found to have abundant existence in malignant thyroid tissues, but its role in thyroid cancer hasn’t been… read more here.
Keywords: thyroid cancer; migration invasion; ddx5; protein ... See more keywords
Low expression of DDX5 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-207002
Abstract: Aims Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies. Hence, there is a need for new markers and treatment strategies. P68/DEAD box protein 5 (DDX5) is an ATP-dependent RNA helicase of the… read more here.
Keywords: ddx5; expression; pancreatic ductal; ddx5 expression ... See more keywords
Abstract 3948: DDX5 helicase resolves G-quadruplex and transactivates MYC expression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3948
Abstract: DDX5 (DEAD-box protein 5) plays an important role in cell proliferation, differentiation, and tumorigenesis. DDX5 is a founding member of the DEAD-box RNA helicase family and known as a non-processive RNA helicase. It acts as… read more here.
Keywords: myc expression; dna; ddx5; helicase ... See more keywords
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
Sign Up to like & getrecommendations! Published in 2020 at "Retrovirology"
DOI: 10.1186/s12977-020-00514-4
Abstract: Background HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was… read more here.
Keywords: factor; tat; ddx5; hiv transcription ... See more keywords
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000772
Abstract: In intestinal epithelial cells (IECs), DDX5 promotes the expression of immune response genes and oncogenes posttranscriptionally and is a novel therapeutic target for treating colitis and intestinal cancers. Tumorigenesis in different segments of the intestinal… read more here.
Keywords: promotes oncogene; oncogene fabp1; tumorigenesis; ddx5 promotes ... See more keywords