The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108903
Abstract: Across the animal kingdom, adult tissue homeostasis is regulated by adult stem cell activity, which is commonly dysregulated in human cancers. However, identifying key regulators of stem cells in the milieu of thousands of genes… read more here.
Keywords: ddx56; box helicase; dead box; cancer ... See more keywords
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2084235
Abstract: ABSTRACT DEAD-box helicase (DDX) family exerts a critical effect on cancer initiation and progression through alternative splicing, transcription and ribosome biogenesis. Increasing evidence has demonstrated that DEAD-box helicase 56 (DDX56) is over-expressed in several cancers,… read more here.
Keywords: cell; box helicase; ddx56; dead box ... See more keywords
DDX56 Binds to Chikungunya Virus RNA To Control Infection
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02623-20
Abstract: Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus… read more here.
Keywords: conserved antiviral; infection; chikungunya virus; ddx56 ... See more keywords
DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.230409
Abstract: ABSTRACT Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide… read more here.
Keywords: irf3 nucleus; ddx56; type interferon; irf3 ... See more keywords
DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72471
Abstract: Rationale: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver that is the leading cause of cancer-related mortality worldwide. However, genetic alterations and mechanisms underlying HCC development remain unclear. Methods: Tissue specimens were used… read more here.
Keywords: pten akt; tumorigenesis; hcc; akt signaling ... See more keywords