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   Articles with "deacetylase" as a keyword



The screening and expression of polysaccharide deacetylase from Caulobacter crescentus and its function analysis

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recommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.2390

Abstract: The bacterium Caulobacter crescentus secretes an adhesive polysaccharide called holdfast, which is the known strongest underwater adhesive in nature. The deacetylase encoded by hfs (holdfast synthesis) H gene is a key factor affecting the adhesion… read more here.

Keywords: deacetylase; caulobacter crescentus; holdfast; polysaccharide deacetylase ... See more keywords

Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases

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recommendations! Published in 2022 at "BioEssays"

DOI: 10.1002/bies.202200110

Abstract: Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates.… read more here.

Keywords: neurological diseases; lysosomal acidification; deacetylase; tubulin deacetylase ... See more keywords

Rutin increases alpha-tubulin acetylation via histone deacetylase 6 inhibition.

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recommendations! Published in 2022 at "Drug development research"

DOI: 10.1002/ddr.21927

Abstract: Microtubules are dynamic cytoskeletal filaments composed of alpha- (α) and beta (β)-tubulin proteins. α-tubulin proteins are posttranslationally acetylated, and loss of acetylation is associated with axonal transport defects, a common alteration contributing to the pathomechanisms… read more here.

Keywords: tubulin acetylation; increases alpha; inhibition; rutin increases ... See more keywords

Identification of phenolic compounds from Zingiber offinale and their derivatives as histone deacetylase inhibitors and antioxidants

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recommendations! Published in 2017 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-017-1785-1

Abstract: The aim of this study was to explore histone deacetylase inhibitory and antioxidant activities of natural products from ginger and their semi-synthetic derivatives. Two major phenolic compounds, [6]-gingerol and [6]-shogaol along with three minor phenolic… read more here.

Keywords: deacetylase; deacetylase inhibitors; histone deacetylase; phenolic compounds ... See more keywords
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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

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recommendations! Published in 2020 at "Cell Reports"

DOI: 10.1016/j.celrep.2020.01.091

Abstract: Summary The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1… read more here.

Keywords: deacetylase; demethylase; corest complex; corest ... See more keywords

The Methyl-CpG Binding Domain 2 and 3 proteins and formation of the Nucleosome Remodeling and Deacetylase complex.

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recommendations! Published in 2019 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.10.007

Abstract: The Nucleosome Remodeling and Deacetylase (NuRD) complex uniquely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex. The Methyl-CpG Binding Domain 2 and 3 (MBD2 and MBD3) proteins provide a critical structural… read more here.

Keywords: deacetylase; binding domain; remodeling deacetylase; methyl cpg ... See more keywords

Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases.

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recommendations! Published in 2024 at "Accounts of chemical research"

DOI: 10.1021/acs.accounts.3c00801

Abstract: ConspectusThe zinc-dependent histone deacetylases (HDACs 1-11) belong to the arginase-deacetylase superfamily of proteins, members of which share a common α/β fold and catalytic metal binding site. While several HDACs play a role in epigenetic regulation… read more here.

Keywords: active site; chemistry; deacetylase; histone deacetylases ... See more keywords

Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure

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recommendations! Published in 2024 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00519

Abstract: Bacteroides are often the most abundant, commensal species in the gut microbiome of industrialized human populations. One of the most commonly detected species is Bacteroides ovatus. It has been linked to benefits like the suppression… read more here.

Keywords: carbohydrate deacetylase; deacetylase; carbohydrate; gut microbe ... See more keywords

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.

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recommendations! Published in 2017 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.6b01609

Abstract: Sirt2 is a target for the treatment of neurological, metabolic, and age-related diseases including cancer. Here we report a series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold. These compounds are potent Sirt2 inhibitors active… read more here.

Keywords: deacetylase; crystal structure; sirt2 inhibitors; structure ... See more keywords

Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila.

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recommendations! Published in 2024 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.4c00847

Abstract: Post-translational modifications are crucial in regulating biological functions across both prokaryotes and eukaryotes. In Aeromonas hydrophila, CobQ, a recently identified novel deacetylase, plays a significant role in lysine deacetylation, influencing bacterial metabolism and stress responses.… read more here.

Keywords: role; aeromonas hydrophila; cobq; regulatory role ... See more keywords

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.

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recommendations! Published in 2019 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.8b00600

Abstract: Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and… read more here.

Keywords: deacetylase; fragile syndrome; histone deacetylase; inhibitor 100 ... See more keywords