The screening and expression of polysaccharide deacetylase from Caulobacter crescentus and its function analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2390
Abstract: The bacterium Caulobacter crescentus secretes an adhesive polysaccharide called holdfast, which is the known strongest underwater adhesive in nature. The deacetylase encoded by hfs (holdfast synthesis) H gene is a key factor affecting the adhesion… read more here.
Keywords: deacetylase; caulobacter crescentus; holdfast; polysaccharide deacetylase ... See more keywords
Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200110
Abstract: Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates.… read more here.
Keywords: neurological diseases; lysosomal acidification; deacetylase; tubulin deacetylase ... See more keywords
Rutin increases alpha-tubulin acetylation via histone deacetylase 6 inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Drug development research"
DOI: 10.1002/ddr.21927
Abstract: Microtubules are dynamic cytoskeletal filaments composed of alpha- (α) and beta (β)-tubulin proteins. α-tubulin proteins are posttranslationally acetylated, and loss of acetylation is associated with axonal transport defects, a common alteration contributing to the pathomechanisms… read more here.
Keywords: tubulin acetylation; increases alpha; inhibition; rutin increases ... See more keywords
Identification of phenolic compounds from Zingiber offinale and their derivatives as histone deacetylase inhibitors and antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1785-1
Abstract: The aim of this study was to explore histone deacetylase inhibitory and antioxidant activities of natural products from ginger and their semi-synthetic derivatives. Two major phenolic compounds, [6]-gingerol and [6]-shogaol along with three minor phenolic… read more here.
Keywords: deacetylase; deacetylase inhibitors; histone deacetylase; phenolic compounds ... See more keywords
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.01.091
Abstract: Summary The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1… read more here.
Keywords: deacetylase; demethylase; corest complex; corest ... See more keywords
The Methyl-CpG Binding Domain 2 and 3 proteins and formation of the Nucleosome Remodeling and Deacetylase complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.007
Abstract: The Nucleosome Remodeling and Deacetylase (NuRD) complex uniquely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex. The Methyl-CpG Binding Domain 2 and 3 (MBD2 and MBD3) proteins provide a critical structural… read more here.
Keywords: deacetylase; binding domain; remodeling deacetylase; methyl cpg ... See more keywords
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01609
Abstract: Sirt2 is a target for the treatment of neurological, metabolic, and age-related diseases including cancer. Here we report a series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold. These compounds are potent Sirt2 inhibitors active… read more here.
Keywords: deacetylase; crystal structure; sirt2 inhibitors; structure ... See more keywords
Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00600
Abstract: Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and… read more here.
Keywords: deacetylase; fragile syndrome; histone deacetylase; inhibitor 100 ... See more keywords
A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03180
Abstract: In this study, we synthesized and characterized a silicon phthalocyanine substituted with 3-hydroxypyridin-2-thione (SiPc-HDACi), designed to be a chemophotodynamic therapy agent acting as a histone deacetylase inhibitor, and we determined its photophysical, photochemical, and photobiological… read more here.
Keywords: histone deacetylase; deacetylase inhibitor; study; phthalocyanine substituted ... See more keywords
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2149973
Abstract: ABSTRACT Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and… read more here.
Keywords: legionella; histone; legionella pneumophila; deacetylase ... See more keywords
Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa214
Abstract: Abstract SIRT6 deacetylase activity improves stress resistance via gene silencing and genome maintenance. Here, we reveal a deacetylase-independent function of SIRT6, which promotes anti-apoptotic gene expression via the transcription factor GATA4. SIRT6 recruits TIP60 acetyltransferase… read more here.
Keywords: deacetylase; independent function; function sirt6; gata4 ... See more keywords