SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.012
Abstract: Glucocorticoids have strong effects on diverse human activities through the glucocorticoid receptor (GR). Sirtuin 1 (SIRT1) is a NAD+-dependent histone deacetylase and promotes longevity by influencing intermediary metabolism and other regulatory activities including mitochondrial function.… read more here.
Keywords: glucocorticoid receptor; transcriptional activity; transcriptional enhancer; deacetylase activity ... See more keywords
O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01654-6
Abstract: SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased… read more here.
Keywords: deacetylase activity; stress; glcnacylation sirt1;
Deacetylase activity-independent transcriptional activation by HDAC2 during TPA-induced HL-60 cell differentiation
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DOI: 10.1371/journal.pone.0202935
Abstract: The human myeloid leukemia cell line HL-60 differentiate into monocytes following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). However, the mechanism underlying the differentiation of these cells in response to TPA has not been fully elucidated. In this… read more here.
Keywords: hdac2; tpa; differentiation; activity independent ... See more keywords