Multicomponent synthesis, binding mode and structure-activity relationships of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups.
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DOI: 10.1021/acs.jmedchem.9b01888
Abstract: The histone deacetylase 6 (HDAC6) is an emerging target for the treatment of cancer, neurodegenerative diseases, inflammation, and other diseases. Here, we present the multicomponent synthesis and structure-activity relationships of a series of tetrazole-based HDAC6… read more here.
Keywords: activity relationships; multicomponent synthesis; histone deacetylase; deacetylase hdac6 ... See more keywords