Design and Synthesis of Terephthalic Acid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Anti‐Plasmodium Activity
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700360
Abstract: In this work we aimed to develop parasite‐selective histone deacetylase inhibitors (HDAC) inhibitors with activity against the disease‐causing asexual blood stages of Plasmodium as well as causal prophylactic and/or transmission blocking properties. We report the… read more here.
Keywords: design synthesis; deacetylase inhibitors; terephthalic acid; histone deacetylase ... See more keywords
Novel histone deacetylase inhibitors bearing a 4‐piperidin‐4‐yl‐triazole scaffold as antitumor agents
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21603
Abstract: Histone deacetylases have proven to be promising targets for the development of anticancer drugs. In this work, we reported the design and synthesis of a series of 20 novel hydroxamic acid‐based histone deacetylase inhibitors with… read more here.
Keywords: novel histone; deacetylase inhibitors; histone deacetylase; piperidin triazole ... See more keywords
Identification of phenolic compounds from Zingiber offinale and their derivatives as histone deacetylase inhibitors and antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1785-1
Abstract: The aim of this study was to explore histone deacetylase inhibitory and antioxidant activities of natural products from ginger and their semi-synthetic derivatives. Two major phenolic compounds, [6]-gingerol and [6]-shogaol along with three minor phenolic… read more here.
Keywords: deacetylase; deacetylase inhibitors; histone deacetylase; phenolic compounds ... See more keywords
Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.02.006
Abstract: The modulation of immature dendritic cells (iDCs), which involves processes such as phagocytosis, migration, and maturation, is considered a beneficial research theme. Once activated by an antigen, iDCs turn to mature DCs (mDCs) and migrate… read more here.
Keywords: immature dendritic; deacetylase inhibitors; migration; histone deacetylase ... See more keywords
Histone deacetylase inhibitors in hepatocellular carcinoma: A therapeutic perspective.
Sign Up to like & getrecommendations! Published in 2018 at "Surgical oncology"
DOI: 10.1016/j.suronc.2018.07.015
Abstract: Hepatocellular carcinoma (HCC) is a major contributor to the global cancer burden. Given the current limited options to treat advanced HCC, understanding the molecular basis of HCC carcinogenesis and pinpointing druggable targets will be important… read more here.
Keywords: hepatocellular carcinoma; hcc; deacetylase inhibitors; histone deacetylase ... See more keywords
Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01593
Abstract: Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising… read more here.
Keywords: deacetylase inhibitors; marbostat 100; potent selective; histone deacetylase ... See more keywords
Coupling Chlorin-Based Photosensitizers and Histone Deacetylase Inhibitors for Photodynamic Chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00170
Abstract: Photodynamic therapy combined with chemotherapy is a promising strategy to improve the antitumor efficacy. On the basis of coupling the chlorin-based photosensitizer pyropheophorbide a (Pyro) and histone deacetylase inhibitors (HDACis) to fabricate dual-mode antitumor molecules,… read more here.
Keywords: chlorin based; antitumor; deacetylase inhibitors; chemotherapy ... See more keywords
Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00390
Abstract: Acanthamoeba is a ubiquitous and free-living protozoan pathogen responsible for causing Acanthamoeba keratitis (AK), a severe corneal infection inflicting immense pain that can result in permanent blindness. A drug-based treatment of AK has remained arduous… read more here.
Keywords: encystation; deacetylase inhibitors; histone deacetylase; hdaci ... See more keywords
Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000685
Abstract: Abstract Epigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions, especially for controlling gene expression. Epigenetic dysregulation plays a key role in disease pathogenesis and… read more here.
Keywords: histone deacetylase; deacetylase inhibitors; hypomethylating agents; epigenetic therapies ... See more keywords
A comparative analysis to determine the optimum histone deacetylase inhibitors and administration route for improving survival and organ injury in rats after hemorrhagic shock.
Sign Up to like & getrecommendations! Published in 2023 at "Shock"
DOI: 10.1097/shk.0000000000002136
Abstract: OBJECTIVE Histone deacetylase inhibitors (HDACIs) have been reported to improve survival in rats with hemorrhagic shock (HS). However, no consensus exists on the most effective HDACIs and their administration routes. We herein aimed to determine… read more here.
Keywords: rats hemorrhagic; administration; tsa; deacetylase inhibitors ... See more keywords
Release of bio‐active dentine extracellular matrix components by histone deacetylase inhibitors (HDACi)
Sign Up to like & getrecommendations! Published in 2017 at "International Endodontic Journal"
DOI: 10.1111/iej.12588
Abstract: AIM To characterize dentine matrix component (DMC) release and smear layer removal by histone deacetylase inhibitors (HDACis). METHODOLOGY DMCs were extracted from powdered human dentine over 14 days using three HDACis, valproic acid (VPA), trichostatin A… read more here.
Keywords: deacetylase inhibitors; matrix; histone deacetylase; smear layer ... See more keywords