Identification of phenolic compounds from Zingiber offinale and their derivatives as histone deacetylase inhibitors and antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1785-1
Abstract: The aim of this study was to explore histone deacetylase inhibitory and antioxidant activities of natural products from ginger and their semi-synthetic derivatives. Two major phenolic compounds, [6]-gingerol and [6]-shogaol along with three minor phenolic… read more here.
Keywords: deacetylase; deacetylase inhibitors; histone deacetylase; phenolic compounds ... See more keywords
Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03305
Abstract: A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor.… read more here.
Keywords: late stage; histone deacetylase; cyclopropane ring; strategy ... See more keywords
Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives
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DOI: 10.3390/molecules27103332
Abstract: Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead… read more here.
Keywords: deacetylase inhibitory; inhibitory activity; activity; histone deacetylase ... See more keywords