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   Articles with "deacetylation" as a keyword



Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3‐Regulated Histone Deacetylation and Transcription

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202307804

Abstract: RNA splicing is crucial in the multilayer regulatory networks for gene expression, making functional interactions with DNA‐ and other RNA‐processing machineries in the nucleus. However, these established couplings are all major spliceosome‐related; whether the minor… read more here.

Keywords: histone deacetylation; minor spliceosomal; spliceosomal 65k; 65k rnpc3 ... See more keywords

NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202412109

Abstract: Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed death ligand 1(PD‐1/PD‐L1) axis showing promise but encountering resistance in a significant patient population. This resistance has… read more here.

Keywords: nad metabolism; cervical cancer; nuclear localization; deacetylation ... See more keywords

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200180

Abstract: Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc‐dependent HDACs, HDAC10 has… read more here.

Keywords: assay hdac10; deacetylation; cellular target; target engagement ... See more keywords

Selective Carbohydrate Deacetylation: Simple and Mild Approach based on Supported Copper Nanoparticles

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recommendations! Published in 2024 at "Helvetica Chimica Acta"

DOI: 10.1002/hlca.202400120

Abstract: Herein, a selective protocol for the complete removal of acetyl protecting groups from carbohydrate derivatives based on copper nanoparticles supported on activated carbon is presented. The deacetylation procedure occurs under neutral conditions, is applicable to… read more here.

Keywords: deacetylation simple; carbohydrate deacetylation; copper nanoparticles; selective carbohydrate ... See more keywords

Ginsenoside Rh2 targets SIRT1-mediated deacetylation to modulate ERα/AR balance and overcome endocrine therapy resistance in prostate cancer using 3D organoid models

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recommendations! Published in 2025 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-025-10091-x

Abstract: Resistance to endocrine therapy remains a major challenge in treating prostate cancer (PCa), highlighting the need for alternative therapeutic approaches. In this study, we investigated the potential of Ginsenoside Rh2 to counteract such resistance by… read more here.

Keywords: resistance; therapy; rh2; prostate cancer ... See more keywords

Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice

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recommendations! Published in 2017 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-017-0476-2

Abstract: The present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore. It also explored whether activating sirtuin… read more here.

Keywords: cypd; group; deacetylation; cognitive dysfunction ... See more keywords

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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recommendations! Published in 2025 at "Science China Life Sciences"

DOI: 10.1007/s11427-024-2616-7

Abstract: The infiltration of glioblastoma multiforme (GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin… read more here.

Keywords: microtubule deacetylation; fsd1; gbm; diffuse infiltration ... See more keywords

Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.06.057

Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.

Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords

HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.04.153

Abstract: Krüppel-like factor 5 (KLF5) is a basic transcription factor that regulates diverse cellular processes during tumor development. Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor… read more here.

Keywords: degradation; acetylation; deacetylation; klf5 ... See more keywords

Simultaneous deacetylation and degradation of chitin hydrogel by electrical discharge plasma using low sodium hydroxide concentrations.

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recommendations! Published in 2020 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2019.115377

Abstract: Electrical discharge plasma occurring in a liquid phase, so called solution plasma, can generate highly active species, e.g. free radicals, which can involve in various chemical reactions, leading to less chemical uses. In this study,… read more here.

Keywords: discharge plasma; electrical discharge; deacetylation; solution ... See more keywords

Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis

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recommendations! Published in 2020 at "Chinese Chemical Letters"

DOI: 10.1016/j.cclet.2019.06.007

Abstract: Abstract The acetyl ester plays an important role for protection of the hydroxyl groups in carbohydrates synthesis. In the present study, we described an efficient deprotection of acetyl group of pentacyclic triterpenoid by using methanolic… read more here.

Keywords: deacetylation; selective facile; pentacyclic triterpenoid; ammonia ... See more keywords