First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200180
Abstract: Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc‐dependent HDACs, HDAC10 has… read more here.
Keywords: assay hdac10; deacetylation; cellular target; target engagement ... See more keywords
Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0476-2
Abstract: The present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore. It also explored whether activating sirtuin… read more here.
Keywords: cypd; group; deacetylation; cognitive dysfunction ... See more keywords
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.057
Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.
Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords
HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.153
Abstract: Krüppel-like factor 5 (KLF5) is a basic transcription factor that regulates diverse cellular processes during tumor development. Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor… read more here.
Keywords: degradation; acetylation; deacetylation; klf5 ... See more keywords
Simultaneous deacetylation and degradation of chitin hydrogel by electrical discharge plasma using low sodium hydroxide concentrations.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115377
Abstract: Electrical discharge plasma occurring in a liquid phase, so called solution plasma, can generate highly active species, e.g. free radicals, which can involve in various chemical reactions, leading to less chemical uses. In this study,… read more here.
Keywords: discharge plasma; electrical discharge; deacetylation; solution ... See more keywords
Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.06.007
Abstract: Abstract The acetyl ester plays an important role for protection of the hydroxyl groups in carbohydrates synthesis. In the present study, we described an efficient deprotection of acetyl group of pentacyclic triterpenoid by using methanolic… read more here.
Keywords: deacetylation; selective facile; pentacyclic triterpenoid; ammonia ... See more keywords
Deacetylation of per-acetatylated glycopyranosides: An overall pattern for acidic catalyzis
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2019.03.022
Abstract: Abstract Acetyl protecting groups are commonly used in carbohydrate chemistry. Partially acetylated arylglycosides are not only useful building blocks in syntheses, but they are also substantial for plant metabolism. Nonselective base catalysis is often used… read more here.
Keywords: deacetylation; per acetatylated; catalyzed deacetylation; chemistry ... See more keywords
Influence of freezing temperature and deacetylation degree on the performance of freeze-dried chitosan scaffolds towards cartilage tissue engineering
Sign Up to like & getrecommendations! Published in 2017 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2017.08.017
Abstract: Abstract Chitosan-based porous structures have been significantly studied across the world as potential tissue engineering scaffolds. Despite the differences in chitosan produced from squid pens or crustacean shells, with the former being more reactive and… read more here.
Keywords: chitosan scaffolds; tissue; deacetylation; freeze dried ... See more keywords
Deacetylation of 3-acetyl-deoxynivalenol in wheat flour is mediated by water-soluble proteins during the making of Chinese steamed bread.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.125341
Abstract: To find the determining factors for 3-acetyl-deoxynivalenol (3-ADON) deacetylation during wheat-based food production, wheat flours with different heat treatments, different matrixes of the starch-gluten mixture, and different protein fractions (Osborne classification) were evaluated. The deacetylation… read more here.
Keywords: deacetylation acetyl; wheat flour; acetyl deoxynivalenol; wheat ... See more keywords
The effect of deacetylation degree of konjac glucomannan on microbial metabolites and gut microbiota in vitro fermentation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103796
Abstract: Abstract Deacetylation was a phenomenon widely existed during konjac glucomannan (KGM) processing, which highly effected its functional properties. Herein, influence of deacetylation degree (DD) of KGM on microbial metabolites and gut microbiota was studied in… read more here.
Keywords: microbial metabolites; konjac glucomannan; deacetylation; metabolites gut ... See more keywords
The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.06.003
Abstract: Summary Chromatin remodeling complexes play essential roles in metazoan development through widespread control of gene expression, but the precise molecular mechanisms by which they do this in vivo remain ill defined. Using an inducible system… read more here.
Keywords: deacetylation; transcription; nucleosome remodeling; gene expression ... See more keywords