Histone Deacetylation Inhibitors as Therapy Concept in Sepsis
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DOI: 10.3390/ijms20020346
Abstract: Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory response occurring in parallel to a hypo-inflammatory reaction. This is often associated with multi-organ failure, leading to the patient’s death. Therefore, reprogramming of these pro-… read more here.
Keywords: histone deacetylation; sepsis; expression; deacetylation inhibitors ... See more keywords
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells
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DOI: 10.3390/ijms21072356
Abstract: Regulatory T cells (Tregs) are important mediators of immunological self-tolerance and homeostasis. Being cluster of differentiation 4+Forkhead box protein3+ (CD4+FOXP3+), these cells are a subset of CD4+ T lymphocytes and can originate from the thymus… read more here.
Keywords: histone deacetylation; inhibitors modulators; regulatory cells; modulators regulatory ... See more keywords