Chemical Probes in Sirtuin Research.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2017.11.014
Abstract: Sirtuins refer to a family of intracellular enzymes that are the yeast silent information regulator 2 (sir2) protein homologs found in organisms from all the three kingdoms of life. This family of enzymes primarily catalyze… read more here.
Keywords: catalyzed deacylation; chemical probes; chemical; reaction ... See more keywords
CAL-B-Catalyzed deacylation of benzylic acetates: Effect of amines addition. Comparison of several approaches.
Sign Up to like & getrecommendations! Published in 2017 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.07.005
Abstract: Herein, we report an efficient enantioselective cleavage of the acyl-moity of some secondary benzylic acetate derivatives catalyzed by lipase B from Candida antarctica (CAL-B) in the presence of triethylamine, as additive, in non aqueous media.… read more here.
Keywords: catalyzed deacylation; cal catalyzed; effect; deacylation ... See more keywords
High-Light-Induced Stress Activates Lipid Deacylation at the Sn-2 Position in the Cyanobacterium Synechocystis Sp. PCC 6803
Sign Up to like & getrecommendations! Published in 2021 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcab147
Abstract: Abstract Cyanobacterial mutants defective in acyl-acyl carrier protein synthetase (Aas) produce free fatty acids (FFAs) because the FFAs generated by deacylation of membrane lipids cannot be recycled. An engineered Aas-deficient mutant of Synechocystis sp. PCC… read more here.
Keywords: lipid deacylation; deacylation; pcc 6803; position ... See more keywords
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1101/2022.11.11.516172
Abstract: KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytically labile covalent acyl-enzyme intermediate. Carbapenems, the most… read more here.
Keywords: tautomer; carbapenem; deacylation; activity ... See more keywords