Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14668
Abstract: Me31B/DDX6 is a DEAD-box family RNA helicase playing roles in post-transcriptional RNA regulation in different cell types and species. Despite the known motifs/domains of Me31B, the in vivo functions of the motifs remain unclear. Here,… read more here.
Keywords: me31b ddx6; rna helicase; germline; dead box ... See more keywords
RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32651
Abstract: Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH.… read more here.
Keywords: ddx5; mtorc1; dead box; nonalcoholic steatohepatitis ... See more keywords
Multiple Functions of the DEAD-Box Helicase Vasa in Drosophila Oogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-319-60855-6_6
Abstract: The DEAD-box helicase Vasa (Vas) has been most extensively studied in the fruit fly, Drosophila melanogaster, and numerous roles for it in germline development have been discovered. Here, we summarize the present state of knowledge… read more here.
Keywords: helicase vasa; box helicase; dead box;
The DEAD-box RNA helicase eIF4A regulates plant development and interacts with the hnRNP LIF2L1 in Physcomitrella patens
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-019-01628-x
Abstract: eIF4A is a RNA-stimulated ATPase and helicase. Besides its key role in regulating cap-dependent translation initiation in eukaryotes, it also performs specific functions in regulating cell cycle progression, plant growth and abiotic stress tolerance. Flowering… read more here.
Keywords: pp3c6 1080v3; physcomitrella patens; eif4a; rna ... See more keywords
Identification, expression analysis, and function evaluation of 42 tomato DEAD-box RNA helicase genes in growth development and stress response
Sign Up to like & getrecommendations! Published in 2018 at "Acta Physiologiae Plantarum"
DOI: 10.1007/s11738-018-2665-0
Abstract: DEAD-box RNA helicases play pivotal roles in almost all processes in RNA metabolisms, associated with various cellular functions including plant development and the response to abiotic stress. Previously, although DEAD-box genes were identified in tomato… read more here.
Keywords: dead box; stress; box; box rna ... See more keywords
Single Molecule FRET Studies on the Mechanism of ATP-Dependent RNA Unwinding by Dead-Box Helicases: An RNA-Induced Movement of the RNA Binding Domain of YxiN Regulates Unwinding by the Helicase Core
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.934
Abstract: DEAD-box proteins catalyze the ATP-dependent unwinding of RNA duplexes. Their common helicase core, formed by two RecA-like domains, is typically flanked by additional domains that modulate helicase function by hitherto unidentified mechanisms. To understand the… read more here.
Keywords: rna; rna binding; dead box; helicase core ... See more keywords
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.12.031
Abstract: Stress granules are condensates of non-translating mRNAs and proteins involved in the stress response and neurodegenerative diseases. Stress granules form in part through intermolecular RNA-RNA interactions, and to better understand how RNA-based condensation occurs, we… read more here.
Keywords: condensation; box protein; rna; dead box ... See more keywords
Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109428
Abstract: NF-κB plays a key role in the transcriptional regulation of genes involved in immunity, inflammation, cell proliferation, and oncogenesis. The NF-κB activation process includes nuclear translocation, followed by association with basal transcription machinery. These steps… read more here.
Keywords: expression level; rna helicase; dead box; phosphorylation p65 ... See more keywords
DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.021
Abstract: Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2)… read more here.
Keywords: box helicase; ddx18; counteracts prc2; dead box ... See more keywords
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108903
Abstract: Across the animal kingdom, adult tissue homeostasis is regulated by adult stem cell activity, which is commonly dysregulated in human cancers. However, identifying key regulators of stem cells in the milieu of thousands of genes… read more here.
Keywords: ddx56; box helicase; dead box; cancer ... See more keywords
Evaluation of antileishmanial potential of computationally screened compounds targeting DEAD-box RNA helicase of Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.053
Abstract: Visceral leishmaniasis (VL) is one of the most devastating diseases of the tropical region caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and vaccine available against this fatal disease. The… read more here.
Keywords: rna helicase; rna; dead box; donovani ... See more keywords