Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1.
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DOI: 10.1038/s42003-022-03186-2
Abstract: Burkholderia pseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that… read more here.
Keywords: lethal factor; basis specificity; molecular basis; deamidation eif4a ... See more keywords