Site‐specific rapid deamidation and isomerization in human lens αA‐crystallin in vitro
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DOI: 10.1002/pro.3821
Abstract: Recent studies have suggested that the isomerization/racemization of aspartate residues in proteins increases in aged tissues. One such residue is Asp151 in lens‐specific αA‐crystallin. Although many isomerization/racemization sites have been reported in various proteins, the… read more here.
Keywords: deamidation isomerization; crystallin; deamidation; isomerization racemization ... See more keywords
Deamidation and isomerization liability analysis of 131 clinical-stage antibodies
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DOI: 10.1080/19420862.2018.1548233
Abstract: ABSTRACT Contemporary in vivo and in vitro discovery platform technologies greatly increase the odds of identifying high-affinity monoclonal antibodies (mAbs) towards essentially any desired biologically relevant epitope. Lagging discovery throughput is the ability to select… read more here.
Keywords: clinical stage; isomerization liability; chemical stability; deamidation isomerization ... See more keywords
Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue
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DOI: 10.1080/19420862.2022.2143006
Abstract: ABSTRACT Deamidation of asparagine (Asn) and isomerization of aspartic acid (Asp) residues are among the most commonly observed spontaneous post-translational modifications (PTMs) in proteins. Understanding and predicting a protein sequence’s propensity for such PTMs can… read more here.
Keywords: deamidation; deamidation isomerization; therapeutic proteins; isomerization ... See more keywords