Theoretical description of the preferential hydrolytic deamination of cytosine over adenine
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2021.113354
Abstract: Abstract It has been shown experimentally that the hydrolytic deamination of cytosine in single-stranded DNA occurs significantly more frequently than that of adenine, despite similarities in their structure. To provide insight into this difference, we… read more here.
Keywords: deamination cytosine; hydrolytic deamination; deamination; cytosine adenine ... See more keywords
Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.03.015
Abstract: The retroviral restriction factors of the APOBEC3 (A3) cytidine deaminase family catalyze the deamination of cytidines in single-stranded viral DNA. APOBEC3C (A3C) is a strong antiviral factor against viral infectivity factor (vif)-deficient simian immunodeficiency virus… read more here.
Keywords: deamination; a3c; hiv; virus ... See more keywords
Determination of oligonucleotide deamination by high resolution mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.05.012
Abstract: A novel analytical approach capable of measuring deaminated degradation products of oligonucleotide therapeutics is described. The method employs high-resolution mass spectrometry to assess the shift in isotopic distribution that accompanies deamination. Isotopic Distribution Factors (IDF),… read more here.
Keywords: deamination; high resolution; mass spectrometry; resolution mass ... See more keywords
Towards a comprehensive understanding of RNA deamination: synthesis and properties of xanthosine-modified RNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac477
Abstract: Abstract Nucleobase deamination, such as A-to-I editing, represents an important posttranscriptional modification of RNA. When deamination affects guanosines, a xanthosine (X) containing RNA is generated. However, the biological significance and chemical consequences on RNA are… read more here.
Keywords: modified rna; deamination; towards comprehensive; rna deamination ... See more keywords
Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02963-22
Abstract: The observation that l-serine uptake occurs as E. coli cultures grow is well established, yet the benefit E. coli garners from this uptake remains unclear. Here, we report a novel acid tolerance mechanism where l-serine… read more here.
Keywords: deamination; acid tolerance; acid; serine ... See more keywords
Immunoglobulin Class Switch Recombination Is Initiated by Rare Cytosine Deamination Events at Switch Regions
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00125-20
Abstract: Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) class switch recombination (CSR), somatic hypermutation (SHM), and gene conversion by converting DNA cytosines to uracils at specific genomic regions. In this study, we examined AID footprints across… read more here.
Keywords: switch region; class switch; aid; deamination ... See more keywords
Mechanistic insights into reductive deamination with hydrosilanes catalyzed by B(C6F5)3: A DFT study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1025135
Abstract: Selective defunctionalization of synthetic intermediates is a valuable approach in organic synthesis. Here, we present a theoretical study on the recently developed B(C6F5)3/hydrosilane-mediated reductive deamination reaction of primary amines. Our computational results provide important insights… read more here.
Keywords: reductive deamination; insights reductive; deamination; c6f5 ... See more keywords
Acceleration of the Deamination of Cytosine through Photo-Crosslinking
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45060298
Abstract: Herein, we report the major factor for deamination reaction rate acceleration, i.e., hydrophilicity, by using various 5-substituted target cytosines and by carrying out deamination at high temperatures. Through substitution of the groups at the 5′-position… read more here.
Keywords: deamination cytosine; cytosine; deamination; acceleration deamination ... See more keywords
Deamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27248849
Abstract: Deamination of 1-aminoalkylphosphonic acids in the reaction with HNO2 (generated “in situ” from NaNO2) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and substitution products (2-hydroxylkylphosphonic acids) as well… read more here.
Keywords: reaction; aminoalkylphosphonic acids; deamination; reaction intermediates ... See more keywords