I2-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines.
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DOI: 10.1021/acs.orglett.0c02001
Abstract: A novel and efficient entrance to the pyrimidine skeleton has been presented via the α,β-dehydrogenation and deamination of tertiary alkylamines. This I2-catalyzed dehydrogenative multicomponent procedure utilizes simple aldehydes to trap the hidden enamine intermediates and… read more here.
Keywords: dehydrogenation deamination; deamination tertiary; tertiary alkylamines; catalyzed aerobic ... See more keywords