I2-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio)pyridazin-3(2H)-ones.
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DOI: 10.1021/acs.orglett.3c00306
Abstract: An unprecedented, one-step strategy for the synthesis of 5-(methylthio)pyridazin-3(2H)-one derivatives has been developed through iodine triggered deaminative coupling of glycine esters with methyl ketones and hydrazine hydrate in DMSO. These transformations in the absence of… read more here.
Keywords: dmso promoted; methylthio pyridazin; glycine esters; promoted deaminative ... See more keywords
Deaminative coupling of benzylamines and arylboronic acids
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DOI: 10.1039/d2sc06055h
Abstract: A metal-free deaminative coupling of non-prefunctionalised benzylamines and arylboronic acids is reported. In this operationally simple reaction, a primary amine in benzylamine is converted into a good leaving group in situ using inexpensive and commercially… read more here.
Keywords: arylboronic acids; benzylamines arylboronic; deaminative coupling; coupling benzylamines ... See more keywords