Copper-catalyzed asymmetric dearomative alkynylation of isoquinolines
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DOI: 10.1039/d0qo00041h
Abstract: Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This novel reaction tolerates a wide… read more here.
Keywords: dearomative alkynylation; catalyzed asymmetric; alkynylation isoquinolines; asymmetric dearomative ... See more keywords
Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles
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DOI: 10.1055/a-1811-8075
Abstract: A catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a variety of alkynes and chromanones. More… read more here.
Keywords: alkynylation chromanones; enantioselective dearomative; opportunities obstacles; dearomative alkynylation ... See more keywords