Enantioselective synthesis of cyclic α-aminoboronates via copper-catalyzed dearomative borylation of 4-quinolinols.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00027j
Abstract: A highly enantioselective and regioselective dearomative borylation of 4-quinolinols was developed using a Cu(I)/(R,R)-Ph-BPE catalyst for efficient synthesis of unprecedented heterocyclic α-amino boronates, a new class of compounds potentially relevant to drug discovery, in generally… read more here.
Keywords: borylation quinolinols; enantioselective synthesis; dearomative borylation; synthesis cyclic ... See more keywords
Copper-catalyzed asymmetric dearomative borylation: new pathway to optically active heterocyclic compounds
Sign Up to like & getrecommendations! Published in 2018 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2017-0912
Abstract: Abstract Chiral N-heterocyclic organoboronates represent promising intermediates for the preparation of various bioactive and pharmaceutical compounds. We recently reported the first asymmetric dearomative borylation of indoles by copper-catalyzed borylation. Then we further developed dearomatization/enantioselective borylation… read more here.
Keywords: enantioselective borylation; borylation; asymmetric dearomative; dearomative borylation ... See more keywords
Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031052
Abstract: Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthesize… read more here.
Keywords: borylation coumarins; methodology; borylation; boron ... See more keywords