Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles.
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DOI: 10.1021/acs.orglett.2c00962
Abstract: Herein, we disclose a strategy for the asymmetric dearomatization of N-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent… read more here.
Keywords: dearomative carbonylation; carbonylation; palladium catalyzed; carbonylation indoles ... See more keywords