Palladium-Catalyzed Dearomative Fluoroallylation of Pyrroles with gem-Difluorinated Cyclopropanes.
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DOI: 10.1021/acs.orglett.5c00817
Abstract: We herein report the development of a novel Pd-catalyzed dearomative functionalization of pyrroles with gem-difluorinated cyclopropanes (gem-F2CPs). This dearomative/ring-opening strategy streamlines the diversity-oriented synthesis (DOS) of α-quaternary 2-fluoroallylic 2H-pyrroles with a broad scope and excellent… read more here.
Keywords: palladium catalyzed; difluorinated cyclopropanes; dearomative fluoroallylation; gem difluorinated ... See more keywords