Electrochemical Dearomative Spirocyclization of N-Acyl Thiophene-2-sulfonamides.
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DOI: 10.1021/acs.orglett.2c02536
Abstract: The Friedel-Crafts type alkylation of C2-tethered thiophenes has been reported to be nonregioselective. Taking advantage of the highly regioselective 5-exo-trig spirocyclization of an electrochemically generated amidyl radical, we have unraveled an electrochemical dearomative spirocyclization of… read more here.
Keywords: spirocyclization; dearomative spirocyclization; acyl thiophene; thiophene sulfonamides ... See more keywords
Synthesis of Difluoromethylated and Phosphorated Spiro[5.5]trienones via Dearomative Spirocyclization of Biaryl Ynones.
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DOI: 10.1021/acs.orglett.8b01027
Abstract: Copper- or silver-catalyzed cascade radical addition/dearomative spirocyclization of biaryl ynones with fluoroalkyl bromides or diethylphosphite has been realized for the first time. This method provides a novel and step-economical protocol for the divergent synthesis of… read more here.
Keywords: spirocyclization biaryl; biaryl ynones; phosphorated spiro; dearomative spirocyclization ... See more keywords