Cobalt-Catalyzed Dearomatization of Indoles via Transfer Hydrogenation To Afford Polycyclic Indolines.
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DOI: 10.1021/acs.orglett.1c00354
Abstract: A cobalt-catalyzed dearomatization of indoles via transfer hydrogenation with HBpin and H2O has been developed. This reaction offered a straightforward platform to access hexahydropyrido[1,2-a]indoles in high regio- and chemoselectivity. A preliminary reaction mechanism was proposed… read more here.
Keywords: catalyzed dearomatization; via transfer; transfer hydrogenation; cobalt catalyzed ... See more keywords
Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines.
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DOI: 10.1021/acs.orglett.2c00530
Abstract: A robust and green electrochemical dearomatization of indoles was developed by merging a fluorine-containing group to an indole nucleus under oxidant-free conditions, delivering a diverse array of tri- and difluoromethylated 3,3-spiroindolines with good functional group… read more here.
Keywords: indoles access; electrochemical dearomatization; access diversified; fluorine containing ... See more keywords
Metal-free synthesis of C2-quaternary indolinones by (NH4)2S2O8 mediated oxidative dearomatization of indoles
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DOI: 10.1039/d2ra04191j
Abstract: An efficient metal-free, (NH4)2S2O8 mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields.… read more here.
Keywords: metal free; oxidative dearomatization; nh4 2s2o8; dearomatization indoles ... See more keywords
Direct Oxidative Dearomatization of Indoles with Aromatic Ketones: Rapid Access to 2,2-Disubstituted Indolin-3-ones
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DOI: 10.1055/s-0039-1691528
Abstract: A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both indoles and aromatic ketones in… read more here.
Keywords: aromatic ketones; oxidative dearomatization; disubstituted indolin; indoles aromatic ... See more keywords