Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-025-00316-1
Abstract: Accumulation of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) are followed by the activation of glia cells and infiltration of peripheral immune cells that collectively accelerate neurodegeneration in preclinical AD models. Yet, the role of neuroinflammation… read more here.
Keywords: disease progression; cell death; death pathways;
Programmed cell death: the pathways to severe COVID-19?
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210602
Abstract: Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts and rapid vaccine development, an uneven vaccine roll-out and the emergence of novel… read more here.
Keywords: cell death; death pathways; death; covid ... See more keywords
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2423358122
Abstract: Significance Phosphoinositide 3-kinases (PI3Ks) phosphorylate the head group of phosphoinositide lipids in the cytoplasmic leaflet of subcellular membranes and thereby regulate signaling and membrane dynamics. The class II PI3K-C2α isoform has recently emerged as a… read more here.
Keywords: endotoxic shock; death pathways; inactivation pi3k; cell death ... See more keywords
Inflammatory cell death in intestinal pathologies
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12602
Abstract: The intestinal tract is a site of intense immune cell activity that is poised to mount an effective response against a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens. The role… read more here.
Keywords: death; intestinal pathologies; inflammatory cell; death pathways ... See more keywords
The evolution of regulated cell death pathways in animals and their evasion by pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reviews"
DOI: 10.1152/physrev.00002.2021
Abstract: The coevolution of host-pathogen interactions underlies many human physiological traits associated with protection from or susceptibility to infections. Among the mechanisms that animals utilize to control infections are the regulated cell death pathways of pyroptosis,… read more here.
Keywords: death pathways; cell death; death; evolution ... See more keywords
Lysosomes in programmed cell death pathways: from initiators to amplifiers
Sign Up to like & getrecommendations! Published in 2017 at "Biological Chemistry"
DOI: 10.1515/hsz-2016-0252
Abstract: Abstract Lysosome is the central organelle for intracellular degradation of biological macromolecules and organelles. The material destined for degradation enters the lysosomes primarily via endocytosis, autophagy and phagocytosis, and is degraded through the concerted action… read more here.
Keywords: death; lysosomal membrane; programmed cell; death pathways ... See more keywords
The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenol-induced Cardiotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Current Pharmaceutical Design"
DOI: 10.2174/1381612825666190619145025
Abstract: Background: Isoproterenol (ISO) is a non-selective β-adrenergic agonist. Our aims were to investigate the autophagy and cell death pathways including apoptosis and necrosis in ISO-induced car-diac injury in a dose-dependent manner. Methods: Male Sprague-Dawley rats… read more here.
Keywords: iso iso; isoproterenol; iso; dose dependent ... See more keywords
Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666181029133041
Abstract: BACKGROUND Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization… read more here.
Keywords: death; group; different cell; death pathways ... See more keywords
Erlotinib Activates Different Cell Death Pathways in EGFR-mutant Lung Cancer Cells Grown in 3D Versus 2D Culture Systems
Sign Up to like & getrecommendations! Published in 2021 at "AntiCancer Research"
DOI: 10.21873/anticanres.14883
Abstract: Background/Aim: Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutation have been shown to have a good response to erlotinib, a receptor tyrosine kinase inhibitor of EGFR. In this study, we found… read more here.
Keywords: death; culture systems; cell death; death pathways ... See more keywords
Targeting Pyroptotic Cell Death Pathways in Retinal Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.802063
Abstract: Pyroptosis is a gasdermin-mediated, pro-inflammatory form of cell death distinct from apoptosis. In recent years, increasing attention has shifted toward pyroptosis as more studies demonstrate its involvement in diverse inflammatory disease states, including retinal diseases.… read more here.
Keywords: cell death; cell; disease; death pathways ... See more keywords
Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9040309
Abstract: It is well appreciated that biological reactive oxygen and nitrogen species such as hydrogen peroxide, superoxide and nitric oxide, as well as endogenous antioxidant systems, are important modulators of cell survival and death in diverse… read more here.
Keywords: regulated cell; death; death pathways; cell death ... See more keywords