C2-substituted 8-aza-7-deaza-2'-deoxyadenosines as environmentally sensitive fluorescent nucleosides for discriminating apurinic/apyrimidinic sites in DNA duplex
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DOI: 10.1016/j.tetlet.2016.11.029
Abstract: Abstract We synthesized various C2-naphthylethynylated 8-aza-7-deaza-2′-deoxyadenosines 1a – 1c as novel environmentally sensitive fluorescent (ESF) purine nucleosides. In particular, the N,N -dimethylamino-substituted derivative 1c exhibits a remarkably high solvatochromicity (Δ λ = 111 nm). 1c -containing oligodeoxynucleotide… read more here.
Keywords: sensitive fluorescent; aza deaza; environmentally sensitive; apurinic apyrimidinic ... See more keywords