Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
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DOI: 10.1016/j.ejmech.2018.07.062
Abstract: Abstract A focused nucleoside library was constructed around a 3′-C-ethynyl-d-ribofuranose sugar scaffold, which was coupled to variously modified purine nucleobases. The resulting nucleosides were probed for their ability to inhibit tumor cell proliferation, as well… read more here.
Keywords: deazapurine; potent antiproliferative; nucleoside library; ethynyl ribofuranose ... See more keywords
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
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DOI: 10.1021/acs.jmedchem.2c01305
Abstract: Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapurine moiety. We… read more here.
Keywords: cdns; design synthesis; dinucleotide; synthesis biochemical ... See more keywords