Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113290
Abstract: Kinetoplastid parasites are the causative agents of neglected tropical diseases with an unmet medical need. These parasites are unable to synthesize the purine ring de novo, and therefore rely on purine salvage to meet their… read more here.
Keywords: antikinetoplastid agents; deazapurine nucleosides; evaluation fluorinated; fluorinated deazapurine ... See more keywords
Impact of 3-deazapurine nucleobases on RNA properties
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab256
Abstract: Abstract Deazapurine nucleosides such as 3-deazaadenosine (c3A) are crucial for atomic mutagenesis studies of functional RNAs. They were the key for our current mechanistic understanding of ribosomal peptide bond formation and of phosphodiester cleavage in… read more here.
Keywords: nucleobases rna; deazapurine nucleobases; deazapurine nucleosides; rna properties ... See more keywords