Estimated Spending on Beremagene Geperpavec for Dystrophic Epidermolysis Bullosa.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.5857
Abstract: Importance New gene therapies can offer substantial benefits to patients, particularly those with rare diseases who have few therapeutic options. In May 2023, the US Food and Drug Administration (FDA) approved the first topical gene… read more here.
Keywords: year; spending; autosomal recessive; autosomal dominant ... See more keywords
Diepoxybutane induces the p53‐dependent transactivation of the CCL4 gene that mediates apoptosis in exposed human lymphoblasts
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23316
Abstract: Diepoxybutane (DEB) is the most toxic metabolite of the environmental chemical 1,3‐butadiene. We previously demonstrated the occurrence of DEB‐induced p53‐mediated apoptosis in human lymphoblasts. The p53 protein functions as a master transcriptional regulator in orchestrating… read more here.
Keywords: deb; ccl4 gene; p53; human lymphoblasts ... See more keywords
A Longitudinal Examination of the Mediating Role of Body Dissatisfaction in the Relationship Between Pornography Use Frequency and Eating Disturbances: A Cross-Lagged Mediation Model
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Sexual Behavior"
DOI: 10.1007/s10508-025-03289-x
Abstract: Albeit a positive association between pornography use frequency (PUF) and body dissatisfaction has been identified, studies examining the link between PUF and disordered eating behavior (DEB) have been highly limited in scope (e.g., only focused… read more here.
Keywords: mediating role; body dissatisfaction; body; deb ... See more keywords
A dynamic energy budget (DEB) model to describe population dynamics of the marine cyanobacterium Prochlorococcus marinus
Sign Up to like & getrecommendations! Published in 2017 at "Ecological Modelling"
DOI: 10.1016/j.ecolmodel.2017.06.011
Abstract: Small but numerically dominant species such as the cyanobacteria Prochlorococcus play a pivotal role in major nutrient cycles. To understand how Prochlorococcus populations affect nutrient flows, we present and analyze two alternative population models. These… read more here.
Keywords: growth; energy budget; budget deb; deb ... See more keywords
Can DEB models infer metabolic differences between intertidal and subtidal morphotypes of the Antarctic limpet Nacella concinna (Strebel, 1908)?
Sign Up to like & getrecommendations! Published in 2020 at "Ecological Modelling"
DOI: 10.1016/j.ecolmodel.2020.109088
Abstract: Abstract Studying the influence of changing environmental conditions on Antarctic marine benthic invertebrates is strongly constrained by limited access to the region, which poses difficulties to performing long-term experimental studies. Ecological modelling has been increasingly… read more here.
Keywords: concinna strebel; intertidal subtidal; limpet nacella; subtidal morphotypes ... See more keywords
Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00530
Abstract: 1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to several reactive epoxide metabolites, and the formation of highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been suggested… read more here.
Keywords: pyr val; exposed workers; diepoxybutane; formation ... See more keywords
Inferring functional traits in a deep-sea wood-boring bivalve using dynamic energy budget theory
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02243-w
Abstract: For species in the deep sea, there is a knowledge gap related to their functional traits at all stages of their life cycles. Dynamic energy budget (DEB) theory has been proven to be an efficient… read more here.
Keywords: dynamic energy; functional traits; deb; deep sea ... See more keywords
DEB-IBM for predicting climate change and anthropogenic impacts on population dynamics of hairtail Trichiurus lepturus in the East China Sea
Sign Up to like & getrecommendations! Published in 2022 at "Conservation Physiology"
DOI: 10.1093/conphys/coac044
Abstract: Abstract The hairtail Trichiurus lepturus supports the largest fisheries in the East China Sea. The stock has fluctuated in the past few decades and this variation has been attributed to human pressures and climate change.… read more here.
Keywords: deb; china sea; model; east china ... See more keywords
Dynamic Energy Budget models: fertile ground for understanding resource allocation in plants in a changing world
Sign Up to like & getrecommendations! Published in 2022 at "Conservation Physiology"
DOI: 10.1093/conphys/coac061
Abstract: Abstract Climate change is having dramatic effects on the diversity and distribution of species. Many of these effects are mediated by how an organism’s physiological patterns of resource allocation translate into fitness through effects on… read more here.
Keywords: deb theory; deb; physiology; resource allocation ... See more keywords
Targeting DNA termini with a small-molecule natural product analogue: a DNA end-binder (DEB) to augment DNA double-strand breaks
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf1027
Abstract: Abstract DNA double-strand breaks generate exposed DNA ends, which, if left unrepaired, can be highly deleterious. Eukaryotic cells have evolved multiple mechanisms to safeguard these DNA ends and maintain genomic integrity. This study screened synthetic… read more here.
Keywords: dna termini; dna end; small molecule; dna ... See more keywords
0897 Dream Enactment Behavior in Veterans with PTSD: The Impact of SSRIs
Sign Up to like & getrecommendations! Published in 2025 at "SLEEP"
DOI: 10.1093/sleep/zsaf090.0897
Abstract: Dream enactment behavior (DEB) has been reported among those with PTSD and a new parasomnia called Trauma Associated Sleep Disorder has been proposed to characterize these sleep difficulties in trauma survivors. The most recent practice… read more here.
Keywords: dream enactment; enactment behavior; deb;