Ubiquitin‐independent, Proteasome‐mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system
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DOI: 10.1002/iub.1945
Abstract: The oncogene KRAS not only promotes the tumorigenesis of pancreatic cancers but also is required for the malignant progression and metastasis of these cancers. Many methods have been explored to influence the malignant biological behavior… read more here.
Keywords: degradation; ornithine decarboxylase; decarboxylase antizyme; targeted degradation ... See more keywords