Nickel/Copper Dual Catalysis for Sequential Nazarov Cyclization/Decarboxylative Aldol Reaction.
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DOI: 10.1021/acs.orglett.8b02426
Abstract: A nickel/copper cocatalyzed sequential Nazarov cyclization/decarboxylative aldol reaction is reported. Various β-hydroxycyclopentenones containing three contiguous stereocenters were prepared in good yields with high diastereoselectivities. A gram-scale reaction and further derivatizations were easily achieved to highlight… read more here.
Keywords: decarboxylative aldol; nickel copper; nazarov cyclization; cyclization decarboxylative ... See more keywords