Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02585
Abstract: An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with… read more here.
Keywords: alkylation unsaturated; methodology; unsaturated carboxylic; decarboxylative alkylation ... See more keywords
Visible-Light-Driven Decarboxylative Alkylation of C-H Bond Catalyzed by Dye-Sensitized Semiconductor.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01077
Abstract: A decarboxylative alkylation of benzylic C(sp3)-H bonds of N-aryl tetrahydroisoquinolines under the irradiation of blue light is reported, featuring a broad substrate scope, low cost, heavy-metal-free, and mild conditions. A preliminary mechanistic study indicated that… read more here.
Keywords: alkylation bond; decarboxylative alkylation; visible light; driven decarboxylative ... See more keywords
Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01866
Abstract: An efficient and mild zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters, to give monofluoroalkenes in moderate to excellent yields with high Z-selectivity is reported. The reaction tolerates a broad range of functional groups… read more here.
Keywords: mediated decarboxylative; decarboxylative alkylation; gem difluoroalkenes; alkylation gem ... See more keywords
Photoinduced ligand to metal charge transfer enabling cerium mediated decarboxylative alkylation of quinoxalin-2(1H)-ones.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00840h
Abstract: Here, we report the cerium-mediated decarboxylative alkylation of quinoxalin-2(1H)-ones utilizing feedstock carboxylic acids as a radical precursor via photoinduced-LMCT. This operationally simple protocol overcomes the limitation of the direct use of carboxylic acids to access… read more here.
Keywords: cerium mediated; alkylation quinoxalin; decarboxylative alkylation; quinoxalin ones ... See more keywords
Visible-Light-Triggered Decarboxylative Alkylation of 8-Acylaminoquinoline with N-Hydroxyphthalimide Ester
Sign Up to like & getrecommendations! Published in 2020 at "Synlett"
DOI: 10.1055/s-0039-1691579
Abstract: A facile protocol for visible-light-induced decarboxylative radical coupling of NHP esters with 8-aminoquinoline amides is reported, affording a highly efficient approach to synthesize a variety of 2-alkylated or 2,4-dialkylated 8-aminoquinoline derivatives. The reaction proceeds smoothly… read more here.
Keywords: alkylation acylaminoquinoline; decarboxylative alkylation; light triggered; triggered decarboxylative ... See more keywords