Decarboxylative chlorination of α,β-unsaturated acids.
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DOI: 10.1039/d5cc03038b
Abstract: Herein, an unprecedented oxidative decarboxylative chlorination of α,β-unsaturated acids for α-chloroketones is reported. This green and sustainable approach employs Fe(III)-catalyzed LMCT to generate a chloride radical from non-hazardous LiCl under violet light irradiation. Molecular oxygen… read more here.
Keywords: chlorination unsaturated; unsaturated acids; decarboxylative chlorination;
Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids
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DOI: 10.1055/s-0039-1690009
Abstract: Chiral α-chloro-α-fluoro ketones were synthesized by enantioselective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with moderate-to-high enantioselectivity (up to 90% ee). The… read more here.
Keywords: halo; synthesis; ketocarboxylic acids; decarboxylative chlorination ... See more keywords