Decarboxylative difluoromethylation of aldehydes with PhSO2CF2COOK: A facile and efficient access to difluoromethylated carbinols
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.07.021
Abstract: Abstract A novel decarboxylative difluoromethylation reaction of PhSO2CF2COOK with aldehydes under metal- and ligand-free conditions has been developed. The reaction is very mild and tolerates a wide range of aldehydes (both enolizable and non-enolizable aldehydes),… read more here.
Keywords: difluoromethylated carbinols; facile efficient; difluoromethylation aldehydes; decarboxylative difluoromethylation ... See more keywords
Copper-Catalyzed Decarboxylative Difluoromethylation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b05363
Abstract: We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can… read more here.
Keywords: decarboxylative difluoromethylation; catalyzed decarboxylative; copper catalyzed;