Biomimetic Total Syntheses of Ergot Alkaloids via Decarboxylative Giese Coupling.
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DOI: 10.1021/acs.orglett.0c03867
Abstract: Biomimetic total syntheses of Festuclavine and Pyroclavine were achieved by a sequential radical coupling. The key steps include intramolecular decarboxylative Giese reaction to form the central C ring and 4-nitrobenzenesulfonyl (Ns)-directed indole C4-H olefination to… read more here.
Keywords: total syntheses; biomimetic total; alkaloids via; decarboxylative giese ... See more keywords
Direct decarboxylative Giese reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d1cs01168e
Abstract: The quest to find milder and more sustainable methods to generate highly reactive, carbon-centred intermediates has led to a resurgence of interest in radical chemistry. In particular, carboxylic acids are seen as attractive radical precursors… read more here.
Keywords: carbon; chemistry; giese reactions; decarboxylative giese ... See more keywords