Construction of Vicinal All-Carbon Stereogenic Centers via Copper-Catalyzed Asymmetric Decarboxylative Propargylation: Enantio- and Diastereoselective Synthesis of Substituted Spirolactones.
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DOI: 10.1021/acs.orglett.2c04113
Abstract: The formation of vicinal all-carbon quaternary stereocenters remains a formidable challenge. We report herein the synthesis of such highly congested structural dyads by copper-catalyzed decarboxylative propargylation between propargyl carbonates and indanone-based nucleophiles. The implementation of… read more here.
Keywords: decarboxylative propargylation; copper catalyzed; copper; vicinal carbon ... See more keywords