Absence of SICKLE triggers programmed cell death by disturbing alternative splicing and decay of mRNAs.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad192
Abstract: Programmed cell death (PCD) plays fundamental roles in plant development and responses to environmental stresses. Here, we report a protein, SICKLE (SIC), that represses PCD. In Arabidopsis (Arabidopsis thaliana), the loss-of-function mutant of SIC, sic-4,… read more here.
Keywords: cell death; alternative splicing; decay; splicing decay ... See more keywords
Slowed decay of mRNAs enhances platelet specific translation.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-08-736108
Abstract: Platelets are anucleate cytoplasmic fragments that lack genomic DNA, but continue to synthesize protein using a pool of messenger RNAs (mRNAs), ribosomes, and regulatory small RNAs inherited from the precursor megakaryocyte (MK). The regulatory processes… read more here.
Keywords: decay mrnas; slowed decay; translation; platelet ... See more keywords