Molecular mechanisms in IL-1β-mediated decorin production by decidual cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab068
Abstract: Decorin, a small leucine-rich proteoglycan produced by decidual cells restrains trophoblast differentiation, migration and invasiveness of extra-villous trophoblast cells. Decidual overproduction of decorin is associated with preeclampsia, and elevated decorin levels in maternal plasma are… read more here.
Keywords: interleukin beta; production; decidual cells; mediated decorin ... See more keywords
Decidualization‐derived cAMP promotes decidual NK cells to be angiogenic phenotype
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13540
Abstract: During early pregnancy, a large number of CD56bright natural killer cells (NKs) are accumulated in the decidua; unlike peripheral and cord blood NK cells (pNK and cNK), these decidual NK cells (dNK) display a great… read more here.
Keywords: decidual cells; decidualization derived; camp promotes; derived camp ... See more keywords
PD‐1 mediates decidual γδ T cells cytotoxicity during recurrent pregnancy loss
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13562
Abstract: Recurrent pregnancy loss (RPL) is one of the big challenges of normal pregnancy. Immune dysregulation has been proposed for the key underline mechanisms of RPL. However, the essential roles of T cells, especially γδ T… read more here.
Keywords: decidual cells; mediates decidual; recurrent pregnancy; pregnancy ... See more keywords
Trophoblast-Derived CXCL16 Decreased Granzyme B Production of Decidual γδ T Cells and Promoted Bcl-xL Expression of Trophoblasts
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DOI: 10.1177/1933719118777638
Abstract: Background: Decidual γδ T cells are known to regulate the function of trophoblasts at the maternal–fetal interface; however, little is known about the molecular mechanisms of cross talk between trophoblast cells and decidual γδ T… read more here.
Keywords: derived cxcl16; production decidual; expression; granzyme production ... See more keywords
Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy.
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DOI: 10.1210/endocr/bqac165
Abstract: The mouse decidua secretes many factors that act in a paracrine/autocrine manner to critically control uterine decidualization, neovascularization, and tissue remodeling that ensure proper establishment of pregnancy. The precise mechanisms that dictate intercellular communications among… read more here.
Keywords: decidual cells; establishment pregnancy; extracellular vesicles; decidualization ... See more keywords
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
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DOI: 10.1371/journal.pbio.3000421
Abstract: Decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential for pregnancy. The decidua is infiltrated by many immune cells promoting pregnancy. Adult bone marrow (BM)-derived cells (BMDCs) differentiate into… read more here.
Keywords: adult; pregnancy; cells contribute; decidual cells ... See more keywords
WISP2/IGF-1 promotes the survival of DSCs and impair the cytotoxicity of decidual NK cells.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-20-0658
Abstract: The survival and development of a semi-allogeneic fetus during pregnancy require the involvement of decidual stromal cells (DSCs), a series of cytokines and immune cells. Insulin-like growth factor 1 (IGF-1) is a low molecular weight… read more here.
Keywords: cytotoxicity; dscs impair; igf; impair cytotoxicity ... See more keywords
Proteogenomic and V(D)J Analysis of Human Decidual T Cells Highlights Unique Transcriptional Programming and Clonal Distribution.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200061
Abstract: Immunological tolerance toward the semiallogeneic fetus is one of many maternal adaptations required for a successful pregnancy. T cells are major players of the adaptive immune system and balance tolerance and protection at the maternal-fetal… read more here.
Keywords: decidual cells; cell; proteogenomic analysis; programming ... See more keywords