GAS6-mediated dialogue between decidual stromal cells and macrophages is essential for early pregnancy maintenance by inducing M2-like polarization and cell proliferation of decidual macrophages.
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DOI: 10.1093/molehr/gaac006
Abstract: Maternal immunotolerance toward the semi-allogeneic fetus is critical for normal pregnancy. As a secretory protein, growth arrest-specific factor 6 (GAS6) promotes cancer progression by inducing the conversion of tumour-associated macrophages to an immunosuppressive M2-like phenotype.… read more here.
Keywords: decidual macrophages; cell proliferation; pregnancy; gas6 ... See more keywords
Immune status of decidual macrophages is dependent on the CCL2/CCR2/JAK2 pathway during early pregnancy
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DOI: 10.1111/aji.13480
Abstract: Decidual macrophages (dMφ) play an important role in the formation of maternal–fetal immune tolerance. However, factors that influence the immune status of dMφ and the related potential mechanisms have not been elucidated to date. read more here.
Keywords: status decidual; macrophages dependent; immune status; decidual macrophages ... See more keywords
SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion
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DOI: 10.3389/fcell.2022.891748
Abstract: Decidual macrophages (dMϕs) play critical roles in the establishment of microhomeostasis at the maternal-fetal interface during pregnancy. Impaired macrophage polarization during early pregnancy is associated with recurrent spontaneous abortion (RSA). In the present study, the… read more here.
Keywords: decidual macrophages; sec5 expression; pregnancy; sec5 ... See more keywords
Dysfunction of Decidual Macrophages Is a Potential Risk Factor in the Occurrence of Preeclampsia
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DOI: 10.3389/fimmu.2021.655655
Abstract: Preeclampsia is a multi-factorial and multi-genetic disorder that affects more than eight million mother and baby pairs each year. Currently, most of the attention to the pathogenesis of preeclampsia has been focused on placenta, but… read more here.
Keywords: occurrence preeclampsia; dysfunction decidual; preeclampsia; immune cells ... See more keywords
Isolation of Decidual Macrophages and Hofbauer Cells from Term Placenta—Comparison of the Expression of CD163 and CD80
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DOI: 10.3390/ijms23116113
Abstract: (1) Background: Placental immune cells are playing a very important role in a successful placentation and the prevention of pregnancy complications. Macrophages dominate in number and relevance in the maternal and the fetal part of… read more here.
Keywords: decidual macrophages; cd80; macrophages hofbauer; hofbauer cells ... See more keywords