Deciphering the allosteric binding mechanism of the human tropomyosin receptor kinase A (hTrkA) inhibitors.
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DOI: 10.2210/pdb6nss/pdb
Abstract: Access to cryptic binding pockets or allosteric sites on a kinase that present themselves when the enzyme is in a specific conformational state offers a paradigm shift in designing the next generation small molecule kinase… read more here.
Keywords: htrka; kinase; deciphering allosteric; biology ... See more keywords