Deciphering the Molecular Effects of Mutations on ATRX Cause ATRX Syndrome: A Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25984
Abstract: α‐thalassemia mental retardation X‐linked (ATRX) syndrome is caused by the dysfunction of ATRFfigX protein. The present study explored the structural consequences influenced by two observed mutations V194I and C220R on ADD domain of ATRX protein… read more here.
Keywords: deciphering molecular; molecular dynamics; atrx syndrome; add domain ... See more keywords
Deciphering the molecular events during arsenic induced transcription signal cascade activation in cellular milieu
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0065-3
Abstract: Anthropogenic sources of arsenic poses and creates unintentional toxico-pathological concerns to humans in many parts of the world. The understanding of toxicity of this metalloid, which shares properties of both metal and non-metal is principally… read more here.
Keywords: deciphering molecular; transcription; events arsenic; molecular events ... See more keywords
Deciphering molecular properties and docking studies of hepatitis C and non‐hepatitis C antiviral inhibitors ‐ A computational approach
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.02.014
Abstract: Background: Hepatitis C is an infectious liver disease with high mortality rate which is caused by Hepatitis C virus. Several treatment methods have been applied to combat this deadly virus including interferons, vaccine and direct… read more here.
Keywords: properties docking; deciphering molecular; antiviral inhibitors; inhibitor ... See more keywords
Deciphering Molecular Embeddings with Centered Kernel Alignment
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.4c00837
Abstract: Analyzing machine learning models, especially nonlinear ones, poses significant challenges. In this context, centered kernel alignment (CKA) has emerged as a promising model analysis tool that assesses the similarity between two embeddings. CKA’s efficacy depends… read more here.
Keywords: molecular embeddings; centered kernel; deciphering molecular; model analysis ... See more keywords
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-02067-w
Abstract: Outer membrane (OM) lipoproteins serve vital roles in Gram-negative bacteria, contributing to their pathogenicity and drug resistance. For these lipoproteins to function, they must be transported from the inner membrane (IM), where they are assembled,… read more here.
Keywords: transport; deciphering molecular; basis lipoprotein; lipoprotein recognition ... See more keywords
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65069-4
Abstract: Biomolecules such as nucleic acids and proteins can undergo liquid-liquid phase separation to form biomolecular condensates with diverse architectures. However, fundamental questions surrounding the biophysical principles that govern condensate architecture and their potential biotechnological applications… read more here.
Keywords: deciphering molecular; hollow condensates; fusion oncoprotein; dna ... See more keywords
Abstract 1229: Deciphering molecular mechanisms of metastasis in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1229
Abstract: Across human cancer, tumors that are high grade, poorly differentiated, and have undergone epithelial-to-mesenchymal transition (EMT) carry a worse prognosis with a high likelihood of metastasizing to distant organs. Despite significant research efforts, metastatic cancers… read more here.
Keywords: cell; cell carcinoma; renal cell; deciphering molecular ... See more keywords
Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window
Sign Up to like & getrecommendations! Published in 2025 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.20255143
Abstract: Aim: Isocitrate lyase is the ancient glyoxylate cycle enzyme that catalyzes isocitrate cleavage into succinate and glyoxylate. The glyoxylate cycle is a key metabolic pathway as indicated by significant data on many host pathogens, which… read more here.
Keywords: isocitrate lyase; chemistry; deciphering molecular; molecular insights ... See more keywords