Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.1449
Abstract: Importance Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether activity and exercise can ameliorate kidney function decline in older… read more here.
Keywords: decline; older adults; physical activity; trial ... See more keywords
Assessment of Plasma Amyloid-β42/40 and Cognitive Decline Among Community-Dwelling Older Adults
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.28634
Abstract: Key Points Question Is plasma amyloid-β42/40 (Aβ42/40) associated with cognitive decline among community-dwelling older adults with memory concerns? Findings In this cohort study of 483 participants from a randomized clinical trial, low plasma Aβ42/40 ratio… read more here.
Keywords: plasma; decline; decline among; plasma amyloid ... See more keywords
Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.31654
Abstract: Key Points Question Are cognitively healthy centenarians resilient against further cognitive decline? Findings In this cohort study of 330 self-reported cognitively healthy centenarians, cognitive trajectories revealed only a slight decline in memory functioning, while other… read more here.
Keywords: association cognitive; risk factors; decline; factors cognitive ... See more keywords
Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.13879
Abstract: Key Points Question Are higher blood pressure, glucose, and low-density lipoprotein cholesterol in stroke survivors associated with cognitive decline? Findings In this cohort study using a meta-analysis of individual participant data from 982 stroke survivors… read more here.
Keywords: decline; associations vascular; vascular risk; risk factor ... See more keywords
Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.31493
Abstract: Key Points Question Is childhood loneliness associated with cognitive decline and incident dementia? Findings In this cohort study of 13 592 participants, childhood loneliness was associated with faster cognitive decline and higher risk of incident dementia… read more here.
Keywords: cognitive decline; dementia risk; decline; childhood loneliness ... See more keywords
Association Between Consumption of Ultraprocessed Foods and Cognitive Decline.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.4397
Abstract: Importance Although consumption of ultraprocessed food has been linked to higher risk of cardiovascular disease, metabolic syndrome, and obesity, little is known about the association of consumption of ultraprocessed foods with cognitive decline. Objective To… read more here.
Keywords: decline; consumption; ultraprocessed food; consumption ultraprocessed ... See more keywords
Association of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.4427
Abstract: Importance Hearing loss is associated with cognitive decline. However, it is unclear if hearing restorative devices may have a beneficial effect on cognition. Objective To evaluate the associations of hearing aids and cochlear implants with… read more here.
Keywords: decline; meta analysis; hearing loss; dementia ... See more keywords
Effects of a Polypill, Aspirin, and the Combination of Both on Cognitive and Functional Outcomes: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.5088
Abstract: Importance Vascular risk factors are associated with cognitive decline but studies addressing individual risk factors have not demonstrated an effect of risk factor management on the preservation of cognition. Few trials have examined the effect… read more here.
Keywords: decline; cognitive functional; risk; randomized clinical ... See more keywords
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2025.1601
Abstract: Key Points Question What is the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD)? Findings In this large, multicohort prognostic study of 4467 participants and 9208 longitudinal… read more here.
Keywords: alzheimer disease; white matter; aging alzheimer; matter ... See more keywords
Association Between Neurocognitive Decline and Visual Field Variability in Glaucoma
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2017.1279
Abstract: Importance Visual field variability may impair detection of glaucoma progression over time. Despite the possible overlap between neurocognitive disorders and glaucoma in older individuals, no study has investigated the association between cognitive changes and visual… read more here.
Keywords: field; visual field; decline; association ... See more keywords
Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2024.3241
Abstract: Importance Older adults with major depressive disorder (MDD) or mild cognitive impairment (MCI) are at high risk for cognitive decline. Objective To assess the efficacy of cognitive remediation (CR) plus transcranial direct current stimulation (tDCS)… read more here.
Keywords: mci; cognitive decline; trial; slowing cognitive ... See more keywords