Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.28377
Abstract: LRRK2 mutations produce end-stage Parkinson’s disease (PD) with reduced nigrostriatal dopamine, whereas, asymptomatic carriers have increased dopamine turnover and altered brain connectivity. LRRK2 pathophysiology remains unclear, but reduced dopamine and mitochondrial abnormalities occur in aged… read more here.
Keywords: dopamine; gki mice; decline age; mice ... See more keywords