Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
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DOI: 10.1021/acs.jmedchem.2c00252
Abstract: Protein arginine methyltransferases (PRMTs) are important therapeutic targets, playing a crucial role in the regulation of many cellular processes and being linked to many diseases. Yet, there is still much to be understood regarding their… read more here.
Keywords: protein arginine; arginine; selective inhibitors; deconstruction reconstruction ... See more keywords