Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/ng.3805
Abstract: Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity of methyltransferases or demethylases, yet discordant methylation patterns have also been observed, which are related to stochastic or uncoordinated molecular processes. We… read more here.
Keywords: methylation; deconvolution heterogeneous; haplotype blocks; tissue ... See more keywords
Abstract 974: Automating deconvolution of heterogeneous bulk tumor genomic data
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-974
Abstract: Tumor heterogeneity has been linked to many measures of poor patient outcome. Despite numerous recent methodological advances, though, reliable estimates of clonal and subclonal architecture remain elusive. We present advances in computational deconvolution of tumor… read more here.
Keywords: deconvolution heterogeneous; automating deconvolution; genomic data; heterogeneous bulk ... See more keywords