Targeted Raman Visualization and Mitigation of α-Synuclein Amyloidogenesis in Living Zebrafish by a Nanobody-Decorated Polydiacetylene.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202411419
Abstract: α-Synuclein (α-Syn) amyloidogenesis is considered a promising diagnostic marker and therapeutic target for Parkinson's disease (PD). Simultaneously visualizing and mitigating α-Syn amyloidogenesis are essential for future PD theranostics, yet they continue to pose an insurmountable… read more here.
Keywords: amyloidogenesis; decorated polydiacetylene; raman visualization; nanobody decorated ... See more keywords
Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.071
Abstract: In this study, a "click and hybridization" strategy was developed for the functionalization of polydiacetylene micelles with a targeting aptamer ligand. Decoration of the nanocarriers with an anti-Annexin A2 sequence efficiently triggered enhanced internalization of… read more here.
Keywords: improved targeting; micelles improved; decorated polydiacetylene; aptamer decorated ... See more keywords