The histopathological and pharmacodynamic effects of intradetrusor decorin injected in a rabbit partial bladder outlet obstruction model
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1518-x
Abstract: Purpose To evaluate whether or not the bladder function can be protected by supporting the detrusor with decorin levels during the fibrotic process.MethodsForty-two male rabbits were divided into three main groups, partial bladder outlet obstruction… read more here.
Keywords: bladder; intradetrusor decorin; partial bladder; outlet obstruction ... See more keywords
Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102661
Abstract: Background Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor. We investigated the anti-fibrotic properties of decorin secreted by peritoneal mesothelial cells. Methods… read more here.
Keywords: anti fibrotic; dialysate decorin; effect; peritoneal dialysis ... See more keywords
Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44473
Abstract: Microcirculatory dysfunction is believed to play an important role in diabetic cardiomyopathy. The small leucine-rich proteoglycan decorin is generally considered a pro-angiogenic factor. Here, we investigate whether overexpression of decorin ameliorates diabetic cardiomyopathy and its… read more here.
Keywords: overexpression decorin; overexpression; vegf; igf1r ... See more keywords
Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13770
Abstract: DECORIN is a prototypical member of the small leucine‐rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse… read more here.
Keywords: proliferation migration; migration ors; ors keratinocytes; mice ... See more keywords
Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling
Sign Up to like & getrecommendations! Published in 2024 at "Experimental Dermatology"
DOI: 10.1111/exd.15133
Abstract: The management of hypertrophic scars (HSs), characterized by excessive collagen production, involves various nonsurgical and surgical interventions. However, the absence of a well‐defined molecular mechanism governing hypertrophic scarring has led to less‐than‐ideal results in clinical… read more here.
Keywords: tgf smad; fibrosis; smad signalling; decorin ... See more keywords
Abstract C030: Serum levels and tumor tissue organization of decorin in pancreatic cancer: Links to chemoresistance and disease aggressiveness
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.panca2023-c030
Abstract: Pancreatic cancer has nearly paralleling incidence and mortality rates. Only 15-20% of the tumors are resectable at presentation, and for the majority of patients the situation is palliative. Treatment options are limited to standard chemotherapy,… read more here.
Keywords: pancreatic cancer; cancer; tumor tissue; decorin ... See more keywords
Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-017-0455-x
Abstract: BackgroundDecorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue… read more here.
Keywords: fibrotic lung; serum biomarker; degraded decorin; decorin ... See more keywords
The neuroregenerative effects of topical decorin on the injured mouse cornea
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01812-6
Abstract: Background The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal nerves increases the risk of dry eye disease… read more here.
Keywords: corneal; cornea; topical decorin; nerve ... See more keywords
The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice
Sign Up to like & getrecommendations! Published in 2025 at "Physiological Reports"
DOI: 10.14814/phy2.70424
Abstract: Physical activity is associated with improvements in insulin sensitivity and muscle function. The proteoglycan decorin is increased in skeletal muscle and plasma in response to exercise, but the biological implications are unknown. We investigated the… read more here.
Keywords: mice; decorin; glucose tolerance; muscle ... See more keywords
Decorin, a growth hormone-regulated protein in humans.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of endocrinology"
DOI: 10.1530/eje-17-0844
Abstract: CONTEXT Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy. Whether GH and… read more here.
Keywords: protein; connective tissue; growth hormone; growth ... See more keywords
The Effect of the Wooden Breast Fibrotic Myopathy in Broilers on Fibrillar Collagen Organization and Decorin-Collagen Binding
Sign Up to like & getrecommendations! Published in 2018 at "Avian Diseases"
DOI: 10.1637/11985-102218-reg.1
Abstract: SUMMARY. The wooden breast myopathy is identified by the palpation of a rigid pectoralis major muscle and results in myofiber necrosis and fibrosis in fast-growing, meat-type broilers. The fibrosis in wooden breast–affected muscle is characterized… read more here.
Keywords: collagen; line; collagen fibril; decorin ... See more keywords